[ÖRFÍ]Fræðsluerindi á Keldum: Maternal non-genetic and environmental effects on allergy development - and how Icelandic Horses can help with the approach

[Birkir Þór]

_
Þessi póstur er sendur tengiliðum við stofnanir, fyrirtæki, félög og 
hópa, til að kynna fræðsluerindi sem haldin eru á Tilraunastöðinni að 
Keldum. Vinsamlegast áframsendið með tölvupósti eftirfarandi upplýsingar 
til ykkar fólks._

*
Fræðsluerindi á Tilraunastöð Háskóla Íslands í meinafræði að Keldum.*

Fyrirlesari:*Dr. **Bettina Wagner, *Department of Population Medicine 
and Diagnostic Sciences, College of Veterinary Medicine, Cornell 
University, Ithaca, NY, USA**

**

Heiti erindis:***Maternal non-genetic and environmental effects on 
allergy development - and how Icelandic Horses can help with the approach *

**

*Fræðsluerindið er haldið í samvinnu við GPMLS/BMC**(Graduate Program in 
Molecular Life Sciences/Biomedical Center, Háskóli Íslands), sjá nánar á 
eftirfarandi vefsloð: http://lifvisindi.hi.is/node/486*

**

Erindið verður haldið _fimmtudaginn 30. október _kl. 12:20, í bókasafni 
Tilraunastöðvarinnar.

/Culicoides/hypersensitivity (summer eczema) is a seasonal IgE-mediated 
allergy, induced by allergens from the salivary glands of /Culicoides/ 
midges. The etiology of allergy is influenced by genetic and 
environmental factors. In addition, maternal acquired immune factors can 
act during the neonatal period and contribute to allergy predisposition. 
Our data suggested that maternal IgE transfer to neonatal foals can 
induce regulatory immune mechanisms in the offspring that may alter 
allergy predisposition. To identify predictors of allergy and obtain 
better understanding of the effects of early-in life allergen exposure 
and maternal non-genetic immune factors on the development of 
/Culicoides/ hypersensitivity, we have established a unique, 
longitudinal allergy model in horses. In a collaborative project between 
Keldur and Cornell University, horses were acquired in Iceland and 
exported to Cornell. Three full-sibling groups (n=14) born in Iceland in 
2011 or at Cornell in 2012 and 2013 were exposed or not to /Culicoides/ 
early-in life and obtained, or did not obtain, maternal /Culicoides/ 
-specific immune parameters at birth participate in the model. The 
allergic phenotypes are evaluated and scored until the young horses are 
3.5 years of age. Multiple immunological parameters are measured monthly 
to identify differences in sensitization to /Culicoides/, antibodies and 
cellular immune responses. About 50% of the original mares that came 
from Iceland developed allergy their second summer at Cornell and 
similarly, 50% of the exported 3 year old horses but with milder 
clinical signs than the mares. The longitudinal analysis of the mare 
sera revealed that many known immune parameters that have been 
correlated with allergy, such as total IgE, show a clear seasonal 
variation and are not suitable as early predictors of allergy. The 
project is ongoing. The overall goal is to identify, yet unknown, early 
mechanisms of allergy regulation and novel biomarkers that predict 
allergy before clinical disease develops.

_______________________________________________________________

Birkir Þór Bragason

Tilraunastöð H.Í. í meinafræði að Keldum


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