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Þessi póstur er sendur tengiliðum við stofnanir, fyrirtæki,
félög og hópa, til að kynna fræðsluerindi sem haldin eru á
Tilraunastöðinni að Keldum. Vinsamlegast áframsendið með
tölvupósti eftirfarandi upplýsingar til ykkar fólks.</u></font><br>
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<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="mso-ansi-language:IS"><br>
Fræðsluerindi á Tilraunastöð Háskóla Íslands í
meinafræði að Keldum.<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="mso-ansi-language:IS"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-ansi-language:IS">Fyrirlesari:<b
style="mso-bidi-font-weight:normal"> Dr. </b></span><b
style="mso-bidi-font-weight:
normal"><span style="mso-ansi-language:EN-US" lang="EN-US">Bettina
Wagner, </span></b><span style="mso-ansi-language:EN-US"
lang="EN-US">Department of Population Medicine
and Diagnostic Sciences, College of Veterinary Medicine, Cornell
University, Ithaca,
NY, USA<b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span
style="mso-ansi-language:EN-US" lang="EN-US"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span style="mso-ansi-language:IS">Heiti
erindis:<b style="mso-bidi-font-weight:normal"> </b></span><b><span
style="mso-ansi-language:EN-US" lang="EN-US">Maternal
non-genetic and environmental effects
on allergy development - and how Icelandic Horses can help
with the approach <o:p></o:p></span></b></p>
<p class="MsoNormal"><strong><span lang="EN-GB"><o:p> </o:p></span></strong></p>
<p class="MsoNormal"><strong><span lang="EN-GB">Fræðsluerindið er
haldið í samvinnu
við GPMLS/BMC</span></strong><strong><span
style="font-weight:normal;
mso-bidi-font-weight:bold" lang="EN-GB"> (Graduate Program in
Molecular Life Sciences/Biomedical
Center, Háskóli Íslands), sjá nánar á eftirfarandi vefsloð:
<a class="moz-txt-link-freetext" href="http://lifvisindi.hi.is/node/486">http://lifvisindi.hi.is/node/486</a><o:p></o:p></span></strong></p>
<p class="MsoNormal"><strong><span lang="EN-GB"><o:p> </o:p></span></strong></p>
<p class="MsoNormal"><span style="mso-ansi-language:IS">Erindið
verður haldið <u>fimmtudaginn
30. október </u>kl. 12:20, í bókasafni Tilraunastöðvarinnar.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ansi-language:IS"><o:p> </o:p></span></p>
<p class="MsoNormal"><i style="mso-bidi-font-style:normal"><span
style="mso-ansi-language:EN-US" lang="EN-US">Culicoides</span></i><span
style="mso-ansi-language:EN-US" lang="EN-US"> hypersensitivity
(summer eczema) is a seasonal
IgE-mediated allergy, induced by allergens from the salivary
glands of <i style="mso-bidi-font-style:normal">Culicoides</i>
midges. The etiology of
allergy is influenced by genetic and environmental factors. In
addition, maternal
acquired immune factors can act during the neonatal period and
contribute to
allergy predisposition. Our data suggested that maternal IgE
transfer to neonatal
foals can induce regulatory immune mechanisms in the offspring
that may alter
allergy predisposition. To identify predictors of allergy and
obtain better
understanding of the effects of early-in life allergen exposure
and maternal
non-genetic immune factors on the development of <i
style="mso-bidi-font-style:
normal">Culicoides</i> hypersensitivity, we have established a
unique,
longitudinal allergy model in horses. In a collaborative project
between Keldur
and Cornell University, horses were acquired in Iceland and
exported to Cornell.
Three full-sibling groups (n=14) born in Iceland in 2011 or at
Cornell in 2012
and 2013 were exposed or not to <i
style="mso-bidi-font-style:normal">Culicoides</i>
early-in life and obtained, or did not obtain, maternal <i
style="mso-bidi-font-style:
normal">Culicoides</i> -specific immune parameters at birth
participate in the
model. The allergic phenotypes are evaluated and scored until
the young horses
are 3.5 years of age. Multiple immunological parameters are
measured monthly to
identify differences in sensitization to <i
style="mso-bidi-font-style:normal">Culicoides</i>,
antibodies and cellular immune responses. About 50% of the
original mares that
came from Iceland developed allergy their second summer at
Cornell and similarly,
50% of the exported 3 year old horses but with milder clinical
signs than the
mares. The longitudinal analysis of the mare sera revealed that
many known
immune parameters that have been correlated with allergy, such
as total IgE,
show a clear seasonal variation and are not suitable as early
predictors of
allergy. The project is ongoing. The overall goal is to
identify, yet unknown,
early mechanisms of allergy regulation and novel biomarkers that
predict
allergy before clinical disease develops. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-ansi-language:IS">_______________________________________________________________<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:10.0pt;mso-ansi-language:IS"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:10.0pt;mso-ansi-language:IS">Birkir
Þór Bragason<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:10.0pt;mso-ansi-language:IS">Tilraunastöð
H.Í. í meinafræði að Keldum<o:p></o:p></span></p>
<p class="MsoNormal"><span
style="font-size:10.0pt;mso-ansi-language:IS"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:10.0pt;mso-ansi-language:IS"><o:p> </o:p></span></p>
<p class="MsoNormal"><span
style="font-size:10.0pt;mso-ansi-language:IS"><o:p> </o:p></span></p>
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